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Gut microbiota metabolizes nabumetone in vitro: Consequences for its bioavailability in vivo in the rodents with altered gut microbiome

  • Lenka Jourova
  • , Pavel Anzenbacher
  • , Zuzana Matuskova
  • , Rostislav Vecera
  • , Jan Strojil
  • , Milan Kolar
  • , Milan Nobilis
  • , Petra Hermanova
  • , Tomas Hudcovic
  • , Hana Kozakova
  • , Miloslav Kverka
  • , Eva Anzenbacherova
  • Palacký University
  • Department of Pharmacology
  • Charles University in Prague
  • Institute of Microbiology of the Academy of Sciences of the Czech Republic
  • Institute of Experimental Medicine of the Czech Academy of Sciences

Research output: Contribution to journal › Article › peer-review

Original languageEnglish
Pages (from-to)1296-1302
Number of pages7
JournalXenobiotica
Volume49
Issue number11
DOIs
StatePublished - 2019
Externally publishedYes

ASJC Scopus Subject Areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Health, Toxicology and Mutagenesis

Keywords

  • bioavailability
  • germ-free mice
  • Gut microbiome
  • imipenem
  • metabolism of drugs
  • pharmacokinetic of nabumetone

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